Evaluation of Cognitive and Motor Neurological Disorders in the Short and Long Term After Surgery for the Removal of a Diffuse Low-grade Glioma of the Supplementary Motor Area (POG-C)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Low-grade Glioma; Motor Disorders; Cognitive Disorders

Treatments: Other: Test battery

Study type: Observational

Funder types: Other

Identifiers

NCT05373394

DR220033

Details and patient eligibility

About

Background : The supplementary motor area is the most common/preferential brain location of LGG. This area plays an important role in many motor and cognitive functions such as motor initiation, bimanual coordination and executive functions. Many studies describe the supplementary motor area syndrome resulting from lesions in this area. News managements for LGGs consisting in intraoperative mapping in awake patients reduce significantly neurological disorders and increase also the overall survival . However, the literature does not provide data concerning motor and cognitive functions in a long term and their consequences in the quality of life of patients.

Objective : The aim of our research project is to identify whether there are some motor or neurocognitive deficit in the short and the long term in a population of patients who have medical story of LGG resection in the supplementary motor area.

Full description

Patients and Methods : 20 patients who have medical story of LGG in the supplementary motor area and 20 patients who have medical story of LGG resection in other locations are recruited. Firstly, patients have to complete a self-assessment questionnaire about their quality of life, sent by regular mail or e-mail. Then, patients are admitted on the same day as their follow up visit and underwent motor and neurocognitive screening tests ( "Bilan des 400 points", Tests of Attentional Performances) for an hour. The investigators will analyse data and compare between the 2 groups.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years of age or older
• Have a history of low-grade diffuse glioma resection
• Visiting the University Hospital for a follow-up neurosurgical consultation
• Underwent awake surgery

Exclusion criteria

• Presence of cognitive disorders that do not allow the proposed test battery to be performed
• Under guardianship or curatorship
• Opposition to the participation to the research

Trial design

22 participants in 2 patient groups

Case

Description:

patients with a history of surgical removal of diffuse low grade glioma located in the supplementary motor area

Treatment:

Other: Test battery

Control

Description:

patients with a history of surgical removal of diffuse low-grade glioma located in another brain area

Treatment:

Other: Test battery