Evaluation of Coronary Microvascular Dysfunction (EVACORY)

Grenoble Alpes University Hospital Center (CHU)

Status

Completed

Conditions

Coronary Artery Disease

Treatments

Procedure: a new non-invasive imaging technique

Study type

Interventional

Funder types

Other

Identifiers

NCT01995955

2012-A00986-37

Details and patient eligibility

About

The proposed study is to validate a new non-invasive imaging technique for evaluation of cardiac microciculation in coronary artery disease with a comparison with validated technique invasive, which is measure of index of myocardial resistance.

Full description

Coronary microvascular dysfunction is closely associated with coronary artery disease, it is an independent risk factor and predicts future coronary events or clinically manifest disease up to 10 years later.

Index of microcirculatory resistance (IMR) is a validated method to Assessment of the Coronary Microcirculation but this is an invasive technique.

In this study, we use a new mathematic technique from homogeneity analysis to provide precise, objective, automated quantification of perfusion heterogeneity at stress with new camera CZT SPECT. We compare the results with those of the measurement of IMR.

Enrollment

45 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Stable angina
Cadmium-zinc-telluride gamma camera SPECT
Coronarography

Exclusion criteria

Pregnant woman
Patient with terminal illness,
Terminal Renal failure
Allergy to iodine
Contraindications for adenosine: Asthmatic patients, Second- or third-degree AV block without a pacemaker or sick sinus syndrome, Systolic blood pressure less than 90mm Hg, Recent use of dipyridamole or dipyridamole-containing medications, Methyl xanthenes such as aminophylline caffeine or theobromine block the effect of adenosine and should be held for at least 12 hours prior to the test, Known hypersensitivity to adenosine, Unstable acute myocardial infarction or acute coronary syndrome