Evaluation of Correlations Between Radiologic Features and Pathologic Subtypes of GGO LUAD Via WMS (ECTOP-1011)

Fudan University

Status: Completed

Conditions: Adenocarcinoma of Lung

Study type: Observational

Funder types: Other

Identifiers

NCT05252676

IRB2106237-23

Details and patient eligibility

About

This study is one of the Eastern Cooperative Thoracic Oncology Projects (ECTOP-1011). It aims to evaluate the correlations between radiologic features and pathologic subtypes of ground glass opacity featured lung adenocarcinoma via whole-mount section.

Full description

The pathological lepidic growth pattern was believed to relate to the ground-glass component, whereas invasive adenocarcinoma patterns relate to the solid component. However, the solid components might be fibrosis rather tumor; and previous studies demonstrated the ground-glass components might be invasive lesions. Therefore, it is of considerable significance to establish the correlations between radiologic features and pathologic subtypes of ground glass opacity featured lung adenocarcinoma.

Enrollment: 103 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ground glass opacity featured lung nodule diagnosed by thin-section computed tomography(TSCT)
• Pre-operation clinical IA stage
• Pulmonary lobectomy or segmentectomy
• Provision of informed consent

Exclusion criteria

• Postoperative diagnosis of non-adenocarcinoma or mucinous adenocarcinoma
• The surgical specimens fail to satisfy requirement of inflation and formalin fixation

Trial design

103 participants in 1 patient group

Patients

Description:

Patients with ground glass opacity featured lung adenocarcinoma who are candidates for surgery.