Evaluation of CPP-ACP Prophylactic Effect on Enamel Surface During Orthodontic Treatment

Cairo University (CU)

Status and phase: Unknown; Phase 1

Conditions: Enamel Hypomineralization; White Spot Lesion

Treatments: Drug: Casein Phosphopeptide-Amorphous Calcium Phosphate Dental Paste

Study type: Interventional

Funder types: Other

Identifiers

NCT03187548

CPP-ACP_whitespots

Details and patient eligibility

About

This study is aiming in preventing the formation of WSL associated with orthodontic treatment which occurs to more than 50% of orthodontically treated patients through applying CPP-ACP on the enamel surface once every 2 weeks for 3 months.

Full description

CPP-ACP will be applied on premolars to be extracted in orthodontic patients whose treatment plan indicates extraction of at least 2 premolaes of the maxillary arch. Application will continue on one premolar either the right or left one once every 2 weeks for the first 3 months of the treatment.

Enrollment: 45 estimated patients

Sex: All

Ages: 15 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• severe crowding
• Increased overjet
• Protruded maxillary base
• Sound maxillary premolars
• medically free
• molar classification class II
• Canine classification class II

Exclusion criteria

• spacing of teeth
• Decreased overjet
• Molar classification III Medically compromised patients
• pregnant females
• carious premolars
• hypoplasia

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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45 participants in 1 patient group

CPP-ACP

Experimental group

Description:

Casein phosphopeptide amorphous calcium phosphate dental paste

Treatment:

Drug: Casein Phosphopeptide-Amorphous Calcium Phosphate Dental Paste