Evaluation of Different Anesthesia for Uterine Curettage (EDAUC)

Nanjing Medical University

Status: Completed

Conditions: Uterine Curettage; Abortion, Induced

Treatments: Drug: Sevoflurane; Drug: Lidocaine; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT00733564

NMU-FY2008-209

NJFY0890-MZ12

Details and patient eligibility

About

Anesthesia during uterine curettage is a problem. Paracervical block is used in general for such an operation, though, the anesthetic efficacy is incomplete. Propofol is the short-lasting intravenous anesthetic administrated popularly. Sevoflurane is a new inhalational anesthetic well-known for it's "easy come, easy go" property. The investigators hypothesized that propofol, sevoflurane and paracervical block had different anesthetic efficacy during uterine curettage. Which one is the optimal selection for such operation needed to be evaluated.

Enrollment: 150 estimated patients

Sex: Female

Ages: 19 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA status I-II
• Performing abortion operation (medical- or surgical)
• Requiring painless abortion

Exclusion criteria

• < 19 yrs, and >=45 yrs
• History of central active drugs administration
• Drug abuse
• Hypertension
• Diabetes
• Any other chronic diseases
• Allergy to the study drugs
• Habit of over-volume alcohol drinking
• Records of history of centrally active drug use and psychiatry
• Any organic disorder

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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150 participants in 3 patient groups

1

Active Comparator group

Description:

Paracervical block will be performed

Treatment:

Drug: Lidocaine

2

Experimental group

Description:

Propofol anesthesia will be performed

Treatment:

Drug: Propofol

3

Experimental group

Description:

Sevoflurane anesthesia will be performed

Treatment:

Drug: Sevoflurane