Evaluation of Different Orthodontic Tooth Movements Assisted With Injectable Platelet Rich Fibrin

Al-Azhar University

Status and phase: Invitation-only; Phase 2; Phase 1

Conditions: Effect of Platelet Rich Fibrin With Different Tooth Movements

Treatments: Biological: injectable platelet rich fibrin

Study type: Interventional

Funder types: Other

Identifiers

NCT05616936

837/140

Details and patient eligibility

About

The present prospective clinical study will be undertaken for assessment of the effect of application of i-PRF on the rate of levelling and alignment, molar distalization& intrusion of anterior teeth in deep bite cases

Full description

Assessment of the effect of application of i-PRF on the rate of levelling and alignment, molar distalization& intrusion of anterior teeth in deep bite cases

Enrollment: 54 estimated patients

Sex: All

Ages: 15 to 22 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:An age range from 15-22 years. Severe crowding or protrusion requiring 1st premolars extractions followed by symmetrical canine retraction.

All permanent teeth present, 3rd molars are excluded. Good oral and general health. No systemic disease/medication that could interfere with orthodontic tooth movement. No previous orthodontic treatment.

Exclusion Criteria:Patient diagnosed to have an indication for non-extraction approach.

Poor oral hygiene or periodontally compromised patient. Patient with craniofacial anomalies or previous history of trauma, bruxism or parafunctions.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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54 participants in 6 patient groups

Group I

Experimental group

Description:

Intervention side: application of i-PRF with distalization of maxillary first molar that will be performed on intervention sides according to a standardized protocol.

Treatment:

Biological: injectable platelet rich fibrin

Group II

No Intervention group

Description:

Control side: distalization of maxillary first molar that will be performed without any intervention

Group A

Experimental group

Description:

levelling and alignment assisted with Injectable Platelet-rich fibrin (i-PRF) according to a standardized protocol.

Treatment:

Biological: injectable platelet rich fibrin

Group B

No Intervention group

Description:

leveling and alignment will be commenced without Injection of Injectable platelet-rich fibrin (i-PRF)

Group a

Experimental group

Description:

Will includes 9 patients who will receive intrusive arch after leveling and alignment assisted Injectable Platelet-rich fibrin (i-PRF) according to a standardized protocol.

Treatment:

Biological: injectable platelet rich fibrin

Group b

No Intervention group

Description:

Will includes 9 patients who will receive intrusive utility arches after leveling and alignment without Injection of Injectable platelet-rich fibrin (i-PRF)