Evaluation of Digit Tip and Split Skin Donor Site Transcriptome

University Hospital Schleswig-Holstein (UKSH)

Status: Active, not recruiting

Conditions: Digit Tip Wound; Split Skin Donor Site

Treatments: Other: Digit Tip Wound; Other: Split Skin Donor Site Wound

Study type: Observational

Funder types: Other

Identifiers

NCT05991765

DigitTip2023

Details and patient eligibility

About

Regrowth of amputated fingertips presents a unique regenerative healing process in mammals, with subcutaneous volume regrowth, restoration of the dactylogram, and suppression of scar formation. In addition, wound healing from split-thickness donor sites shows almost scar-free healing. Transcriptome analysis is necessary to better understand the specific healing mechanisms of these two wound entities. Since no data are available to date, this study aims to fill the gap.

Full description

Regrowth of amputated fingertips presents a unique regenerative healing process in mammals, with subcutaneous volume regrowth, restoration of the dactylogram, and suppression of scar formation. In addition, wound healing from split-thickness donor sites shows almost scar-free healing. Transcriptome analysis is necessary to better understand the specific healing mechanisms of these two wound entities. Since no data are available to date, this study aims to fill the gap.

Enrollment: 75 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Digit Tip Wound: Wound Exudate from healthy patients: Consent-capable patients ≥18 years of age with clean Digit Tip Wound
2. Split Skin Donor Site Wound: Wound Exudate from healthy patients: Consent-capable patients ≥18 years of age with clean Split Skin Donor Site Wound

Exclusion criteria

• Inflammation
• Borderline
• Infectious Disease

Trial design

75 participants in 2 patient groups

Digit Tip Wound

Description:

Experimental Wound Exudate from Digit Tip Wounds

Treatment:

Other: Digit Tip Wound

Split Skin Donor Site Wound

Description:

Active Comparator Wound Exudate from Split Skin Donor Site Wound

Treatment:

Other: Split Skin Donor Site Wound