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Evaluation of Diode Laser and Topical Steroid Therapy in the Treatment of Erosive Oral Lichen Planus

A

Alexandria University

Status

Completed

Conditions

Erosive Oral Lichen Planus

Treatments

Drug: 0.1% topical triamcinolone Acetonide preparation "Kenacourt-A Orabase"
Device: 980nm Diode Laser

Study type

Interventional

Funder types

Other

Identifiers

NCT05951361
0369-01/2022

Details and patient eligibility

About

this study evaluates the effect of diode laser in treatment of oral lichen planus.

Full description

44 patients with erosive oral lichen planus were included in the study and divided into 2 equal groups. Group I received topical steroid therapy three times daily for 4 weeks and antifungal oral gel once daily for 1 week. Group II received 980nm Diode Laser 300 mW, up to 10 sessions.

Enrollment

44 patients

Sex

All

Ages

30 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patient histologically diagnosed with erosive OLP based on WHO modified criteria 2003.
  • Presence of painful erosive OLP lesions diagnosed by biopsy

Exclusion criteria

  • Pregnant or breast-feeding women
  • Patients currently treated for cancer with Chemotherapy or Radiotherapy
  • Patient currently on Corticosteroid therapy or had this treatment on the past 3 months
  • Those who had used Anti-inflammatory drugs topical or systemic in the last month
  • the use of drugs related to Oral Lichenoid Lesions
  • Presence of Amalgam restorations near the OLP lesions
  • dysplasia in histopathological examination
  • uncontrolled systemic diseases
  • physical or mental abnormality which would interfere with or be affected by the study procedure
  • Patients with skin lesion

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

44 participants in 2 patient groups

Kenacourt-A Orabase
Active Comparator group
Description:
the patients in this group received steroid therapy" Kenacourt-A Orabase" three times daily for 4 weeks. antifungal drug "miconazole oral gel" once daily for 1 week
Treatment:
Drug: 0.1% topical triamcinolone Acetonide preparation "Kenacourt-A Orabase"
980nm Diode Laser
Active Comparator group
Description:
the patients received 980 nm diode laser treatment 300 mW, non-contact mode up to 10 sessions
Treatment:
Device: 980nm Diode Laser

Trial documents
1

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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