Evaluation of Diode Laser and Topical Steroid Therapy in the Treatment of Erosive Oral Lichen Planus

Alexandria University

Status: Completed

Conditions: Erosive Oral Lichen Planus

Treatments: Drug: 0.1% topical triamcinolone Acetonide preparation "Kenacourt-A Orabase"; Device: 980nm Diode Laser

Study type: Interventional

Funder types: Other

Identifiers

NCT05951361

0369-01/2022

Details and patient eligibility

About

this study evaluates the effect of diode laser in treatment of oral lichen planus.

Full description

44 patients with erosive oral lichen planus were included in the study and divided into 2 equal groups. Group I received topical steroid therapy three times daily for 4 weeks and antifungal oral gel once daily for 1 week. Group II received 980nm Diode Laser 300 mW, up to 10 sessions.

Enrollment: 44 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient histologically diagnosed with erosive OLP based on WHO modified criteria 2003.
• Presence of painful erosive OLP lesions diagnosed by biopsy

Exclusion criteria

• Pregnant or breast-feeding women
• Patients currently treated for cancer with Chemotherapy or Radiotherapy
• Patient currently on Corticosteroid therapy or had this treatment on the past 3 months
• Those who had used Anti-inflammatory drugs topical or systemic in the last month
• the use of drugs related to Oral Lichenoid Lesions
• Presence of Amalgam restorations near the OLP lesions
• dysplasia in histopathological examination
• uncontrolled systemic diseases
• physical or mental abnormality which would interfere with or be affected by the study procedure
• Patients with skin lesion

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

44 participants in 2 patient groups

Kenacourt-A Orabase

Active Comparator group

Description:

the patients in this group received steroid therapy" Kenacourt-A Orabase" three times daily for 4 weeks. antifungal drug "miconazole oral gel" once daily for 1 week

Treatment:

Drug: 0.1% topical triamcinolone Acetonide preparation "Kenacourt-A Orabase"

980nm Diode Laser

Active Comparator group

Description:

the patients received 980 nm diode laser treatment 300 mW, non-contact mode up to 10 sessions

Treatment:

Device: 980nm Diode Laser