Evaluation of Effects on Skin Quality of a Centella Asiatica Extracellular Vesicle-based Skin Care Formulation.

Hungkuang University

Status: Completed

Conditions: Skin Elasticity; Skin Redness; Melanin Hyperpigmentation; Skin Wrinkles; Skin Quality; Skin Hydration

Treatments: Other: Centella asiatica extracellular vesicle formulation

Study type: Interventional

Funder types: Other

Identifiers

NCT06850935

24-064-A

Details and patient eligibility

About

The study evaluates the effects of a skin care formulation containing Centella asiatica extracellular vesicles as the main active ingredient on facial appearance and skin quality in healthy participants.

Full description

Twenty healthy participants will be enrolled and will first undergo a 24-hour skin patch test on the forearm to assess potential irritation or allergic reactions to the test product. After screening, participants were asked to use the test product twice daily (morning and evening) after cleansing their face without using exfoliating products for 28 consecutive days. Each application involved 2 drops, evenly applied to the face using fingertips for absorption. Product usage was self-recorded, and the products were stored at room temperature.

The skin quality tests were conducted at the investigation site Hungkuang University onsite by the principal investigator. Each participant was to allocate 1 hour per test (including cleansing and waiting time). Skin quality tests were performed as a baseline test on day 0 (before using the test product), and subsequent tests at 7, 14, 21, and 28 days after test product use.

Measured parameters during assessment will include skin hydration, melanin content, skin elasticity, wrinkle percentage, redness area percentage, and pore percentage.

Enrollment: 20 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adults of any gender from the age of 18 to 60 years (inclusive).
• Absence of chronic diseases, major illnesses, or allergies.

Exclusion criteria

• Currently using any medications or other skincare products

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Centella asiatica extracellular vesicle formulation

Experimental group

Description:

Water-based formulation containing purified Centella asiatica extracellular vesicle as main active ingredient.

Treatment:

Other: Centella asiatica extracellular vesicle formulation