Evaluation of Efficacy and Safety of General Anesthesia Using Dexmedetomidine With Sevoflurane in Patients Undergoing Arthroscopic Shoulder Surgery: Preliminary Study

Yonsei University

Status: Completed

Conditions: Arthroscopic Shoulder Surgery in the Beach-chair Position

Treatments: Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT01687868

4-2012-0351

Details and patient eligibility

About

Patients undergoing shoulder arthroscopy in the beach chair position may be at risk for adverse neurologic events due to cerebral ischemia.

Dexmedetomidine, a potent alpha adrenoceptor agonist which dose-dependently reduces arterial blood pressure and heart rate, decreases the hemodynamic and catecholamine response in the perioperative period.

dexmedetomidine has an effect of peripheral vasoconstriction thus it is theologically appropriate for reducing bleeding for arthroscopic operation field.

The aim of this study is to evaluate the efficacy and the safety of dexmedetomidine on cerebral oxygen saturation, cognitive function, hemodynamic stability and operative field in patients undergoing arthroscopic shoulder surgery in the beach-chair position.

Enrollment: 19 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II
• Aged between 20 and 70 year
• general anesthesia for arthroscopic shoulder surgery in the beach-chair position

Exclusion criteria

• Congestive heart failure, coronary artery occlusive disease
• Bradycardia < 50 BPM, 2nd degree < AV block
• Poorly controlled hypertension
• ß blocker medication
• Coagulopathy
• Pregnancy, nursing

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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19 participants in 1 patient group

dexmedetomidine continuous infusion

Experimental group

Treatment:

Drug: Dexmedetomidine