Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema

Fayoum University

Status: Enrolling

Conditions: Empyema, Pleural

Treatments: Drug: Moxifloxacin + meronam; Drug: Levofloxacin + cefipime; Drug: Levofloxacin + clindamycin

Study type: Interventional

Funder types: Other

Identifiers

NCT06787885

M721

Details and patient eligibility

About

To evaluate the impact of using different antibiotic regimens including single and combined agents as the empirical therapy and evaluate the clinical outcomes regarding safety, efficacy, and pharmacodynamics parameters.

Enrollment: 90 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Confirmed Diagnosis of Empyema: Patients with a clinical and radiological diagnosis of

Exclusion criteria

1 - Hypersensitivity or Allergy to the selected antibiotic: Patients with a known history of hypersensitivity or allergic reactions to used antibiotics.

2- Pregnancy and Lactation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 3 patient groups

Patient with empyema

Other group

Description:

Tavanic (levofloxacin )and dalacin (clindamycin)

Treatment:

Drug: Levofloxacin + cefipime

Empyema patient

Other group

Description:

Tavanic (levofloxacin) and cefipime

Treatment:

Drug: Levofloxacin + clindamycin

patient has lung empyema

Other group

Description:

Moxiflox (moxifloxacin) and meronem

Treatment:

Drug: Moxifloxacin + meronam