Evaluation of Emotion-related Salivary Molecular Biomarkers (EMJOY)

Sys2Diag

Status

Enrolling

Conditions

Emotion

Treatments

Other: Identication and measurement of a molecular biomarkers signature

Study type

Observational

Funder types

Other

Identifiers

NCT07320040

2022-A02008-35

22.03698.000189 (Other Identifier)

Details and patient eligibility

About

Recent studies show that emotional states can be discriminated by physiological responses. This physiological regulation results from the action of enzymes and hormones that represent the activity of the autonomic nervous system. The measurement of specific biomarkers, using non-invasive biological tests in saliva, would therefore provide physiological data on an individual's emotional state in response to stimuli, particularly olfactory stimuli.

Full description

Recent studies show that emotional states (positive and negative) can be discriminated by physiological responses. This physiological regulation stems from the action of enzymes and hormones that represent the activity of the autonomic nervous system. The measurement of specific biomarkers (enzymes, hormones), using non-invasive biological tests in saliva, would therefore provide physiological data on an individual's emotional state (Giacomello et al. 2020) in response to stimuli, particularly olfactory stimuli.

The aim of the proposed research is to identify and measure a signature of molecular biomarkers in saliva, linked to emotions following one or more olfactory stimuli (e.g. cortisol and alpha-amylase concentration increase after stimulation).

Enrollment

240 estimated patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Subject willing to follow study procedures
Subject able to understand the purpose, nature and methodology of the study
Subject has signed informed consent form
Subjects between 18 and 60 years of age.

Exclusion criteria

Subjects deprived of liberty, protected adults, vulnerable persons or minors
Subjects with a proven or suspected chronic infectious disease that could entail a risk of contamination during sample handling (laboratories not equipped to handle this type of sample)
Rejection to sign the consent form.

Non specific inclusion criteria:

Pregnant or breastfeeding women
Subjects presenting anosmia during the last 15 days
Subjects presenting symptoms and signs of active oral inflammation, advanced periodontitis or severe gingivitis.