Evaluation of Endoplasmic Reticulum Stress in Patients With Recurrent Pregnancy Loss

Kanuni Sultan Suleyman Training and Research Hospital

Status: Completed

Conditions: Endoplasmic Reticulum Stress; Recurrent Pregnancy Loss

Treatments: Other: x box binding protein

Study type: Observational

Funder types: Other

Identifiers

NCT04455256

tgk-xbp

Details and patient eligibility

About

To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who had healthy births in the same age group. The level of the unfolded protein X box binding protein 1 (XBP-1) is measured. It is aimed to show the effect of endoplasmic reticulum stress on recurrent pregnancy loss.

Enrollment: 90 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• with three or more miscarriages before 20 th week of gestation
• had no chronic or acute inflammatory disease
• used no steroids, anti-inflammatory, or antioxidant medications

Exclusion criteria

• had inflammatory diseases
• had systemic disease
• Anatomical abnormalities, infectious, endocrine, or genetic etiologies

Trial design

90 participants in 2 patient groups

recurrent pregnancy loss group

Description:

Women between the ages of 18 and 45 who had a history of miscarriage under 3 weeks and above 22 weeks were included in this group.

Treatment:

Other: x box binding protein

women who had healthy birth

Description:

Women between the ages of 18-45 who have not had a history of pregnancy loss and who have had at least one healthy birth and no known chronic diseases are included in this group.

Treatment:

Other: x box binding protein