Evaluation of Esophageal Injuries in Corrosives in Assiut Governorate - Experimental Comparison Between Different Treatments

Assiut University

Status: Unknown

Conditions: Clinico-epidemiological Characteristics of Corrosive Patients Presenting at Assiut Governorate

Treatments: Behavioral: development of complications or not

Study type: Observational

Funder types: Other

Identifiers

NCT03729440

EsophagealCorrosiveAssiut

Details and patient eligibility

About

Esophageal stricture is one of the most common sequelae of caustic injury. Up to 70% of patients with grade IIB and more than 90% of patients with grade III injury are likely to develop esophageal stricture. Stricture formation can be prevented by suppressing fibrosis and scar formation therefore; many agents are explored for treatment on various models in this subject.

Full description

In spite of the multiple efforts to educate the public, Caustic ingestion maintains its place as an important public health issue due to the availability of caustic agents and the loose regulatory control on its production. All the cases will be evaluated by detailed history and thorough physical examination and necessary investigations. Patient's sheet will include; name, age, sex, occupation, residence, type of administrated substance, route and mode of exposure, symptoms and sighs (pain , vomiting , diarrhea) and any received treatment.

Enrollment: 50 estimated patients

Sex: All

Ages: 6 months to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

-1- All the cases with the primary diagnosis of acute caustic injury will be included in the study.

2- Willing and able to comply with the study procedures and provide written informed consent to participate in the study.

Exclusion criteria

• 1- Caustic substance ingested patient with any chronic disease. 2- Patients with history of congenital esophageal stricture. 3- Unable to provide informed consent. 4- Unlikely to return at 8 weeks. 5- Ingestion of substances other than corrosive (co-ingestion).

Trial design

50 participants in 1 patient group

corrosive patients

Treatment:

Behavioral: development of complications or not