Evaluation of Fetal Cardiac Function and Vascular Hemodynamics in Intrauterine Growth Restriction

Assiut University

Status: Completed

Conditions: Fetal Hypoxia

Study type: Observational

Funder types: Other

Identifiers

NCT03108040

AUN80

Details and patient eligibility

About

Intrauterine growth restriction (IUGR) is one of the major contributors to perinatal mortality and morbidity and is characterized by complex hemodynamic changes involving placental and fetal arterial, cardiac and venous circulations .However, the temporal sequence of these modifications in relation to other hemodynamic changes of the fetal arterial and venous circulations is unknown.

The aim of this study was to evaluate cardiac function and other hemodynamic changes in a group of fetuses with IUGR and clinical impact on perinatal outcome .

Enrollment: 534 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Singleton fetus with normal fetal anatomy documented a detailed sonogram.
• Fetal abdominal circumference <5th percentile for gestational age.
• Evidence of placental insufficiency documented by an elevated umbilical artery pulsatility index (UA-PI) by reference ranges.

Exclusion criteria

• evidence of fetal infection
• chorioamnionitis
• fetal anomalies
• abnormal fetal karyotype
• patient withdrawal from the study and/or unavailability for follow-up.