Evaluation of Finastride Effect in Different Dosage on the Amount of Perioperative Bleeding in Transurthral Resection of Prostate (TURP)

Shiraz University of Medical Sciences

Status and phase: Completed; Phase 3; Phase 2

Conditions: Benign Prostate Hyperplasia

Treatments: Procedure: TURP

Study type: Interventional

Funder types: Other

Identifiers

NCT01627522

89-01-01-2395

Details and patient eligibility

About

Preoperative use of finastride will decrease the amount of perioperative blood loss during and after TURP

The effect of finastride on decreasing the amount of perioperative blood loss during and after TURP is dose dependent

Finastride will decrease microvascular density in prostate tissue and this effect is dose dependent

Enrollment: 60 patients

Sex: Male

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with BPH that require TURP

Exclusion criteria

• Previous prostate surgery
• Prostate Cancer
• Coagulopathy
• The use of NSAIDs, Anticoagulants, Antiplatelet drugs
• CRF/ESRD

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups

Finastide low dose

Active Comparator group

Description:

2 weeks of daily 5mg finastride before operation

Treatment:

Procedure: TURP

Finastide high dose

Active Comparator group

Description:

4 weeks of daily 5mg finastride before operation

Treatment:

Procedure: TURP

Control

No Intervention group

Description:

Control