Evaluation of Galectin-3 Levels in GCF And Saliva of Patients With Different Periodontal Diseases

Cairo University (CU)

Status: Completed

Conditions: Periodontal Diseases

Treatments: Diagnostic Test: saliva obtaining; Diagnostic Test: GCF obtaining

Study type: Observational

Funder types: Other

Identifiers

NCT05281796

1512022

Details and patient eligibility

About

The aim of this study is to assess the levels of galectin-3 in the GCF and saliva in patient with gingivitis and patient with stage III periodontitis.

Full description

The aim of this study is to assess the levels of galectin-3 in the GCF and saliva in patient with gingivitis and patient with stage III periodontitis.

This study will be conducted in the Oral Medicine and Periodontology department, Faculty of Dentistry- Cairo University, Egypt.

Patients will be selected from the outpatient clinic of the department of Oral Medicine and Periodontology, Faculty of Dentistry-Cairo University.

Enrollment: 66 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. For healthy group: individuals with less than 10% bleeding on probing area, having a probing depth less than 4mm and no loss of attachment were included in the study.
2. For the gingivitis group: individuals with 10% or more bleeding on probing area, having a probing depth of less than 4mm and no attachment loss.
3. For the periodontitis group that has not received periodontal treatment in the last 6 months
4. For the periodontitis group: individuals with 30% or more bleeding on probing area, at least 2 teeth not adjacent to each quarter jaw with a depth of 5 mm or more and 4 mm or more attachment loss, coronal 1/3 and more on radiography (horizontal and / or vertical) bone loss.
5. Presence of a minimum of 15 natural teeth.

Exclusion criteria

1. Individuals with any known systemic disease.
2. Pregnant and lactating women.
3. Individuals that received periodontal treatment within the last 6 months.
4. Individuals with a history of systemic antibiotics and anti-inflammatory drugs within the last 3 months.
5. Former or current smokers.

Trial design

66 participants in 3 patient groups

healthy patient

Description:

Full-mouth clinical periodontal measurements recorded, saliva and GCF obtained

Treatment:

Diagnostic Test: saliva obtaining

Diagnostic Test: GCF obtaining

gingivitis patient

Description:

Full-mouth clinical periodontal measurements recorded, saliva and GCF obtained

Treatment:

Diagnostic Test: saliva obtaining

Diagnostic Test: GCF obtaining

patients with Stage III periodontitis

Description:

Full-mouth clinical periodontal measurements recorded, saliva and GCF obtained

Treatment:

Diagnostic Test: saliva obtaining

Diagnostic Test: GCF obtaining