Evaluation of Granulosa Cells Function After IVF Protocols

Hospital de Clinicas de Porto Alegre

Status: Unknown

Conditions: Infertility; In Vitro Fertilization Protocols

Treatments: Drug: randomization between the two GnRH analogues (agonist and antagonist)

Study type: Interventional

Funder types: Other

Identifiers

NCT01946022

HCPA (Other Identifier)

13-0120

Details and patient eligibility

About

This study is intended to evaluate ovarian cells after being submitted do different in vitro fertilization protocols. The investigators will analyze hormones secretion and intracellular mechanisms of these cells comparing the GnRH agonist protocol and the GnRH antagonist protocol.

Enrollment: 28 estimated patients

Sex: Female

Ages: 20 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient age limit: 39 years
• Follicle Stimulating Hormone (FSH) < 10 micrometer (mU) / Liter
• Antral follicular count > 12
• Regular menses (25 to 35 days)
• More than 3 oocytes after ovarian punction
• Anti Mullerian between 1 e 3 ng/ml

Exclusion criteria

• Patients submitted to intracytoplasmatic sperm injection (ICSI)
• Ovarian mass or cyst
• Clinical / endocrine pathologies

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

28 participants in 2 patient groups

GnRH Agonist

Active Comparator group

Description:

GnRH long agonist protocol of invitro fertilization

Treatment:

Drug: randomization between the two GnRH analogues (agonist and antagonist)

GnRH Antagonist

Active Comparator group

Description:

GnRH fixed antagonist protocol of in vitro fertilization

Treatment:

Drug: randomization between the two GnRH analogues (agonist and antagonist)