Evaluation of GvHD Damage on Medullary Mesenchymal Stem Cells

Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna

Status: Enrolling

Conditions: Graft Vs Host Disease

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05167188

GvHD damage on MSCs

Details and patient eligibility

About

Spontaneous, multicenter, prospective, non-pharmacological study. At the diagnosis of acute or chronic GvHD after HSCT, bone marrow cells will be analysed for MSC content and properties. Bone marrow aspirate will be performed according to usual clinical practise

Enrollment: 25 estimated patients

Sex: All

Ages: 6 months to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients (children and adults) developing acute or chronic GvHD after HSCT.
• Age 6 months- month-99 years,
• Landsky-Karnofsky> 70%,
• Acute or chronic GvHD needing further immunosuppressive treatment.

Exclusion criteria

• Anything not included in the inclusion criteria.