Evaluation of Heart Rate Variability and Endothelial Function Three Months After Bariatric Surgery

R

Rio de Janeiro State University

Status

Completed

Conditions

Obesity

Treatments

Procedure: Bariatric Surgery

Study type

Interventional

Funder types

Other

Identifiers

NCT03911479
HRV_endo

Details and patient eligibility

About

Was performed a longitudinal, study with twenty patients recruited for the bariatric surgery group and 20 for clinical treatment. The analysis of HRV and endothelial function were performed through peripheral arterial tonometry, in patients with obesity before and after three months of bariatric surgery. Were also analyzed GLP-1, insulin and glucose at fast, and 30 and 60 minutes. The results were compared in parallel with a control group with clinical treatment for obesity.

Full description

To assess the pathophysiological mechanisms that leads the benefits in cardiovascular risk after bariatric surgery, through the autonomic nervous system and endothelial function, was performed a longitudinal, study with twenty patients recruited for the bariatric surgery group and 20 for clinical treatment. The analysis of HRV and endothelial function were performed through peripheral arterial tonometry, in patients with obesity before and after three months of bariatric surgery. Were also analyzed GLP-1, insulin and glucose at fast, and 30 and 60 minutes. The results were compared in parallel with a control group with clinical treatment for obesity.

Enrollment

40 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with obesity grade 3 [Body Mass Index (BMI) ≥ 40kg/m2] or grade 2 (BMI 35-39.9kg/m2) with comorbidities

Exclusion criteria

Current use of incretin mimetics or inhibitors of dipeptidyl peptidase-4 (DPP4); and history of a previous cardiovascular event (acute myocardial infarction, stroke or peripheral obstructive arterial disease)

Trial design

40 participants in 2 patient groups

Bariatric Surgery Group
Experimental group
Treatment:
Procedure: Bariatric Surgery
Clinical Threatment
Other group
Description:
Convencional treatment in a public tertiary outpatients care unit
Treatment:
Procedure: Bariatric Surgery

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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