Evaluation of Hepatic Fibrosis on Multiparametric MRI

Seoul National University

Status: Unknown

Conditions: Hepatitis; Cirrhosis

Treatments: Diagnostic Test: Liver MRI

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03085342

SNUH-2015-2993

Details and patient eligibility

About

As cirrhosis progresses, alteration of hemodynamics develops and decreased portal flow is often observed. Since direct measurement of portal pressure (HVPG) is invasive, non-invasive methods have drawn a lot of attention. MRI is one of the non-invasive methods and it is able to provide multiparametric data in one examination. Herein, we evaluate hepatic fibrosis with different stage using multiparametric MRI with emphasis on portal flow measurement.

Enrollment: 49 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic liver disease (viral hepatitis, alcoholic hepatitis, or other...)
• Or transplant recipient for viral hepatitis and on anti-viral agent medication
• AND scheduled for liver resection, biopsy or transient elastography
• AND signed informed consent

Exclusion criteria

• younger than 18 years
• any contra-indication for contrast-enhanced MRI
• pregnant or nursing women
• biliary obstruction
• unable or unwilling to give informed consent

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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49 participants in 1 patient group

Liver MRI

Experimental group

Description:

Liver MRI including noncontrast (precontrast) flow measurement, DCE, DWI using multiple b-values, MRE and MR fat quantification.

Treatment:

Diagnostic Test: Liver MRI