Evaluation of IgY Antibody Efficacy in Egg Yolk Against Helicobacter Pylori in Bacterial Elimination and Clinical Symptoms Improvement of Gastrointestinal Patients (Hp IgY)

Mashhad University of Medical Sciences

Status and phase: Completed; Phase 2

Conditions: Gastrointestinal Disease; HELICOBACTER PYLORI INFECTIONS

Treatments: Biological: Helicobacter pylori eradication therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT06973889

IR.MUMS.REC.1401.381

Details and patient eligibility

About

1. Investigating its effectiveness in removing bacteria in invivo conditions
2. Investigating the effectiveness in improving the clinical symptoms of patients

Enrollment: 60 patients

Sex: All

Ages: 18 to 78 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with gastritis or stomach ulcers whose Helicobacter infection has been confirmed by a doctor and age group 18 to 78 years, all genders, if accepted

Exclusion criteria

• Acute perforation of esophagus, stomach and duodenum Hyperlipidemic people Those who are allergic to egg proteins Patients with stomach cancer

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

Intervention

Experimental group

Description:

12 grams of egg yolk powder containing about 2 grams of antibody twice a day for 2 weeks along with usual antibiotic treatment including OAC or omeprazole (40 mg/day), clarithromycin (1000 mg/day) and amoxicillin (2000 mg/day).

Treatment:

Biological: Helicobacter pylori eradication therapy

Control

No Intervention group

Description:

normal egg yolk powder without IgY in the amount of 12 grams 2 times a day for 2 weeks along with usual antibiotic treatment OAC or omeprazole (40 mg/day), clarithromycin (1000 mg/day) and amoxicillin (2000 mg/day)