Evaluation of IL-6 in Synovial Fluid in Obese and Normal Weight Patients Suffering From Gonarthrosis During PTA (IL6PG)

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Status: Completed

Conditions: IL-6 Concentration in the Synovial Fluid of Obese Patients is 100% Higher Than the IL-6 Concentration of the Synovial Fluid in Normal Weight Patients

Treatments: Diagnostic Test: Evaluation of IL-6 biomarkers in synovial fluid

Study type: Observational

Funder types: Other

Identifiers

NCT05145504

IL6PG

Details and patient eligibility

About

Evaluate the concentration of IL-6 in the synovial fluid of obese patients suffering from gonarthrosis during knee arthroplasty surgery

Enrollment: 37 patients

Sex: All

Ages: 55 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age between 55 and 85 years inclusive,
• Normal weight patients with BMI 18-24.9 included
• Obese patients with BMI ≥ 30
• Patients suffering from gonarthrosis awaiting knee arthroplasty surgery
• Patients awaiting knee replacement surgery
• Patients who agree to sign informed consent

Exclusion criteria

• Patients under 55 years of age.
• Patients over 85 years of age
• Patients suffering from diabetes mellitus
• Patients who are unable to understand
• Patients with severe neurological disorders or severe disability
• Rheumatoid arthritis patients
• Cancer patients
• Patients on immunosuppressive therapy

Trial design

37 participants in 2 patient groups

20 obese patients, with BMI ≥ 30

Treatment:

Diagnostic Test: Evaluation of IL-6 biomarkers in synovial fluid

20 normal weight patients with BMI between 18.5 - 24.9 inclusive

Treatment:

Diagnostic Test: Evaluation of IL-6 biomarkers in synovial fluid