Evaluation of Immune Function in Biliary Atresia Children With Prolonged Jaundice

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National Taiwan University

Status

Unknown

Conditions

Biliary Atresia

Study type

Observational

Funder types

Other

Identifiers

NCT00155194
9361701170

Details and patient eligibility

About

Null hypothesis of this study: Biliary atresia patients with cholestatic jaundice do not have systemic immunity defect.

Full description

Biliary atresia patients with cholestatic jaundice were noted to have increased incidence of infectious complications. Previous animal models of bile duct ligation with acute jaundice ever demonstrated impairment of both humoral and cellular immune function. We performed the immunity study in biliary atresia patients due to the lack of comprehensive systemic immunity study in pediatric cholestatic model. Systemic humoral immunity (total serum IgG, IgA, IgM, C3 and C4), specific cellular immunity (lymphocyte classification, mitogen response, cytokines level after PHA stimulation test), and non-specific cellular immunity (absolute neutrophil count, PMN CD11b/CD18 expression level, PMN superoxide release function, and PMN phagocytosis function) were tested. Association with serum bilirubin level, nutritional status and blood biochemical values were tested to see the relation between systemic immune function and cholestatic jaundice.

Sex

All

Ages

1+ year old

Volunteers

No Healthy Volunteers

Inclusion criteria

Biliary patients older than 1-year-old status post Kasai operation.

Exclusion criteria

Received liver transplantation, immunosuppresant, systemic immunoglobulin (within 6 months) and obvious infectious episode (within 2 weeks).

Trial contacts and locations

1

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Central trial contact

Jia-Feng Wu, MD

Data sourced from clinicaltrials.gov

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