Evaluation of Immunoregulatory Cells in Hematopoietic Stem Cell Transplant

Vanderbilt University

Status: Completed

Conditions: Graft vs Host Disease; Hematopoietic Stem Cell Transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT00179049

BMT 030261

Details and patient eligibility

About

The investigators' hypothesis is that the graft-versus-tumor effect can be enhanced while minimizing the complications of graft-versus-host disease.

Full description

The investigators' hypothesis is that the graft-versus-tumor effect can be enhanced while minimizing the complications of graft-versus-host disease (GVHD) by determining the qualitative and quantitative changes in T regulatory cells throughout the transplant process. Their understanding of this can lead to new treatment strategies and improved clinical therapeutic implications.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 18-70 years old undergoing either autologous transplant or allogeneic transplant for various hematologic conditions

Exclusion criteria

• Patients < 18 or > 70 years old undergoing either autologous transplant or allogeneic transplant