Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.

University of Milano Bicocca

Status: Enrolling

Conditions: Myeloproliferative Disease; Inflammatory Markers

Study type: Observational

Funder types: Other

Identifiers

NCT05553873

INFLA-ME

Details and patient eligibility

About

This study aims to observe inflammatory biomarkers and their trend over the history of the disease in patients suffering from MPN Ph negative; it also wants to identify any correlations between the aforementioned biomarkers and disease outcomes, considering first of all the occurrence of thrombo-haemorrhagic events and the evolution in the accelerated / blast phase of the disease, shedding light on new tools that can potentially guarantee a prompt and better risk stratification

Enrollment: 500 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years at the time of diagnosis of MPN Ph negative
• Diagnosis of PV, ET, PMF or post PV and post ET MF, according to current WHO or IWG-MRT criteria (diagnosis since 2000)
• Obtaining informed consent

Exclusion criteria

• Life expectancy of less than 6 months
• Accelerated phase myelofibrosis or MPN with signs of leukemic evolution