Evaluation of Insecticide Treated Nets and Wall Liners for the Prevention of Malaria (MTC-ITWL)

Centers for Disease Control and Prevention (CDC)

Status and phase: Completed; Phase 3

Conditions: Malaria

Treatments: Other: Insecticide treated nets and wall liners; Other: Insecticide treated nets alone

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT01043796

CDC-NCZVED-5794

Details and patient eligibility

About

The purpose of this study is to determine whether insecticide treated wall liners, in combination with insecticide treated nets, reduce the incidence of malaria infections compared to insecticide treated nets alone.

Full description

Insecticide treated nets (ITNs) have been shown to reduce malaria related morbidity and mortality and are increasingly being scaled up throughout sub-Saharan Africa. However, ITNs alone are unlikely to reduce transmission to zero in most settings and additional vector control tools are necessary. One new promising strategy is the use of insecticide treated wall liners (ITWLs). These are textiles treated with an insecticide that are used to line the inner walls of houses. The wall liners are considered a long-lasting alternative to indoor residual spraying which is also used for malaria vector control but is expensive to implement.

Within 6 pairs of villages, we plan to randomly allocate one village in each pair to receive either ITNs or ITNs plus ITWLs. Households will be randomly selected from each village and all children between the ages of 6 months and 11 years will be enrolled in a cohort study. The children will be cleared of existing infections and then followed monthly until they are found to be infected with malaria. The study will last for 6 months and will demonstrate whether the ITWLs provide additional protection against malaria over that provided by the use of ITNs.

Enrollment: 1,730 patients

Sex: All

Ages: 6 months to 11 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 6 months up to 11 years
• Living in the study area and remaining in the study area for the duration of the study
• Informed consent provided by parents

Exclusion criteria

• No informed consent
• Living outside the study area, or likely to move outside study area
• Severely ill and unlikely to be able to complete study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1,730 participants in 2 patient groups

Insecticide treated nets and wall liners

Experimental group

Treatment:

Other: Insecticide treated nets and wall liners

Insecticide treated nets alone

Active Comparator group

Treatment:

Other: Insecticide treated nets alone