Evaluation of Intestinal Microbiota Implication in Ruptured Intracranial Aneurysm (AneBiote)

Civil Hospices of Lyon

Status: Not yet enrolling

Conditions: Intracranial Sacciform Aneurysm

Treatments: Biological: analysis of foecal microbiota

Study type: Observational

Funder types: Other

Identifiers

NCT05914636

2021-A02202-39 (Other Identifier)

69HCL21_0263

Details and patient eligibility

About

The physiopathology of intracranial aneurysm from initiation to ruptured is incompletely understood but included inflammation. The microbiota is known to interact with brain and can promote inflammation. The objective of this study is to describe microbiota with taxonomic and metabolomic analysis. A comparison between ruptured and unruptured intracranial aneurysm will be performed. The study hypothesis is that microbiota is different between ruptured and unruptured patient.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• one or more intracranial sacciform aneurysm ruptured or not in function of the inclusion group

Exclusion criteria

• Transient modification of microbiota: Antibiotherapy in the last 3 months, pre or probiotic in the last month, gastrostomy, ileostomy, bariatric surgery, digestive tract resection, gastro-duodenal ulcer surgery or during the last month, chronic inflammatory disease of the digestive tract (like Crohn), BMI for more than 30, Very restrictive diet (like vegan
• Specific pathologies increasing the incidence of aneurysm ( kidney autosomic dominant polycystosis, Type 1 neurofibromatosis, Rendu-Osler, MArfan
• Participation to a study with the objective of microbiota modification

Trial design

50 participants in 2 patient groups

Ruptured

Description:

Patient with a ruptured intracranial sacciform aneurysm for all location. The diagnosis of ruptured aneurysm is made on MRI, Angio-CT or digital substraction angiography with no doubt

Treatment:

Biological: analysis of foecal microbiota

unruptured

Description:

Patient with an unruptured intracranial sacciform aneurysm for all location. The diagnosis of unuptured aneurysm is made on MRI, Angio-CT or digital substraction angiography with no doubt

Treatment:

Biological: analysis of foecal microbiota