Evaluation of Intestinal Secretion of Antibodies and Auto-antibodies Associated With Crohn's Disease

Public Assistance-Hospitals of Marseille (AP-HM)

Status: Completed

Conditions: Crohn's Disease

Treatments: Other: Blood sampling and biopsy; Other: Biopsy and blood sampling

Study type: Interventional

Funder types: Other

Identifiers

NCT00769236

2008-A00080-55

2008-05

Details and patient eligibility

About

We propose to study the intestinal secretion of ASCA by evaluating them in biopsy culture supernatants from a cohort of patients suffering from CD (n=80) and a cohort of control patients (UC (n=40) and patients without IBD (n=40 )).

Full description

Its diagnosis is based upon clinical, endoscopic and histological parameters but recent studies have shown that seric evaluation of immunological markers (anti-Saccharomyces cerevisiae antibodies (ASCA), anti-neutrophil cytoplasmic auti-antibodies (ANCA)) could be useful. Crohn's disease (CD) is an inflammatory bowel disease (IBD) of the young people. Antibodies anti-chitobisoside carbohydrate (ACCA), anti-laminaribioside carbohydrate (ALCA) and anti-mannobioside carbohydrate (AMCA) have been described as new serological markers of CD.

Enrollment: 160 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients reached by disease of crohn
• patients reached by hemorrhagic first side-colitis

Exclusion criteria

• Forms ileales or ano-périneales pure of disease of crohn
• indefinite colitis

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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160 participants in 3 patient groups

1

Other group

Description:

Patients with crohn disease

Treatment:

Other: Blood sampling and biopsy

2

Other group

Description:

Patients reached by hemorrhagic first side-colitis

Treatment:

Other: Biopsy and blood sampling

Other: Biopsy and blood sampling

3

Other group

Description:

Patients controls

Treatment:

Other: Biopsy and blood sampling

Other: Biopsy and blood sampling