Evaluation of iPRF With Vit.D As an Adjunct to Non-Surgical Therapy in the Treatment of Stage III Periodontitis

Cairo University (CU)

Status and phase: Not yet enrolling; Phase 2

Conditions: Periodontal Pocket

Treatments: Drug: PMPR+iPRF+Vit.D; Procedure: PMPR+iPRF; Procedure: PMPR only

Study type: Interventional

Funder types: Other

Identifiers

NCT06570200

CairoU50022

Details and patient eligibility

About

a clinical trial will be made to investigate the effect of locally applied injectable prf (iPRF) plus vitamin D on the periodontal pockets in stage III periodontitis patients

Full description

in this clinical trial, the treatment of periodontal pockets in stage III periodontitis patients will be evaluated. the study participants will be divided in 3 groups:

First group >> will be treated with professional mechanical plaque removal (PMPR) only.

second group >> will be treated with PMPR + locally applied iPRF.

Third group >> will be treated with PMPR + locally applied iPRF + vitamin D.

Then the results will be compared after 6 months of the treatment (clinically and radiographically).

Enrollment: 45 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients with healthy systemic condition.
2. Adult patients ˃ 18 years old.
3. Patients with Stage III periodontitis.
4. Patients accept 3-month follow-up period (cooperative patients).
5. Patients provide an informed consent.

Exclusion criteria

1. Presence of prosthetic crowns.
2. Extensive interproximal restorations.
3. Periodontal therapy within the last 12 months.
4. Having undergone surgical periodontal therapy or undergoing orthodontic treatment.
5. Ongoing drug therapy that might have an impact on the clinical signs and symptoms of periodontitis.
6. The use of antibiotics or anti-inflammatory drugs 3-month prior to the procedure and till the end of 6-month of follow-up.
7. Smokers.
8. Pregnant females.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Triple Blind

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45 participants in 3 patient groups

PMPR only

Active Comparator group

Description:

scaling and root planing only will be made for group 1 (control group)

Treatment:

Procedure: PMPR only

PMPR + iPRF

Experimental group

Description:

scaling and root planing plus locally applied iPRF in the periodontal pocket will be made for test group 1.

Treatment:

Procedure: PMPR+iPRF

PMPR + iPRF + Vit.D

Experimental group

Description:

scaling and root planing plus locally applied iPRF and vitamin D in the periodontal pocket will be made for test group 2. vitamin D will be obtained from a commercial product in the Egyptian pharmacies called (Devarol S) in the form of injectable ampoules containing 200000 IU of cholecalciferol (2.5 mg/ml)

Treatment:

Drug: PMPR+iPRF+Vit.D