Evaluation of Ketamine and Multi-modal Analgesics

University of Florida

Status: Withdrawn

Conditions: Pain

Treatments: Drug: Ketamine; Drug: Neurontin; Drug: Acetaminophen; Drug: Lidocaine

Study type: Observational

Funder types: Other

Identifiers

NCT02815111

IRB201600316

Details and patient eligibility

About

The purpose of this research study is to see if pain can be better controlled with fewer side effects. The new drug regimen will study several different medicines that have different ways of treating pain.

Full description

The investigators plan to study an analgesic regimen of Ketamine and Lidocaine as infusions with Neurontin and acetaminophen delivered orally for postoperative analgesia and the subsequent effect on ventilator days and ICU stay. The investigators expect that pain scores will be either unchanged or better than historic controls. In addition, the investigators expect that ventilator days and ICU stay will be improved due to reduced incidence of delirium and bowel dysfunction.

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) status 1-4
• Undergoing planned surgery for cardiac problems
• 18 years of age and not older than 85 years of age

Exclusion criteria

• Severe liver disease (alanine aminotransferase (ALT) , aspartate aminotransferase (AST), or bilirubin > 2.5 times Upper Limit of Normal)
• Pregnancy or currently breastfeeding
• History of schizophrenia or other hallucinatory psychiatric disorder
• History of chronic or pre-existing pain disorder
• History of heart block
• Severe renal impairment Creatinine Clearance (CrCl)<30 milliliter(mL)/min

Trial design

0 participants in 2 patient groups

Control Group

Description:

Intensivists will proceed with analgesia utilizing conventional opioid based pain order sets.

Study Group

Description:

The investigators plan to study an analgesic regimen of Ketamine and lidocaine as infusions with Neurontin and Acetaminophen delivered orally for postoperative analgesia and the subsequent effect on ventilator days and ICU stay.

Treatment:

Drug: Lidocaine

Drug: Neurontin

Drug: Acetaminophen

Drug: Ketamine