Evaluation of Kidney Disease in Liver Transplant Recipients

University of Wisconsin (UW)

Status: Withdrawn

Conditions: Liver Transplantation; Kidney Disease

Study type: Observational

Funder types: Other

Identifiers

NCT00585429

H-2006-0335

Details and patient eligibility

About

A non-invasive urinary test that detects kidney injuries in liver transplant (LT) candidates would be useful for monitoring of kidney damage. Particularly, the ability to predict irreversibility of such renal damage or progressive nature of renal disease in LT candidates would be of importance to determine the need for dual kidney-liver transplantation (KLT) versus LT alone. We will correlate kidney histology with cytokine/chemokine profile expression in the urine as a potentially useful noninvasive diagnostic tool.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects on the liver transplant wait list, subjects who have received a liver transplant at least 6 months prior to enrollment, or subjects who have normal liver function and are about to undergo kidney biospy for diagnostic purposes.

Exclusion criteria

• Contraindication to kidney biopsy
• Inability to give informed consent

Trial design

0 participants in 3 patient groups

1

Description:

ESLD subjects on active liver transplant waiting list

2

Description:

Subjects post-liver transplant with good liver function

3

Description:

Subjects without liver disease undergoing kidney biopsy for diagnostic purposes