Evaluation of LB in THA

O

OSF Healthcare System

Status

Completed

Conditions

Hip Disease

Treatments

Drug: Bupivacaine liposome

Study type

Observational

Funder types

Other

Identifiers

NCT03341104
hipstudy2017

Details and patient eligibility

About

This study aims to compare the effectiveness of liposomal bupivacaine (LB) versus standard of practice local injection containing plain bupivacaine.

Full description

Investigation of liposomal bupivacaine to determine if this drug is a valid alternative to standard of care local anesthesia based on evaluation in total hip arthroplasty This is a retrospective cohort study of consecutive patients undergoing THA at 3 hospitals within a U.S. healthcare system from January 2013 to July 2016. The control group received the standard of care undergoing THA (plain bupivacaine or ropivacaine), while the LB group received a mixture containing this drug as the alternative to the standard care. The outcome variables include hospital length of stay, readmissions, total hospital costs, patient pain scores, discharge disposition, morphine equivalent opioid consumption, and postoperative patient ambulation. Generalized linear models were employed to examine aforementioned outcomes controlling for age, gender, race, BMI, alcohol use, tobacco use, and surgeons..

Enrollment

173 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Males or females over the age of 18
  • have undergone a THA surgery during the period of interest January 2013 to July 2016).

Exclusion criteria

excluded from the study based on the following criteria:

  • Concurrent, painful, physical condition or concurrent surgery that may require analgesic treatment in the postoperative period for pain that is not strictly related to the surgical treatment;
  • Uncontrolled anxiety, schizophrenia, or other psychiatric disorder; and
  • Significant renal or hepatic insufficiency.

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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