Evaluation of Left Ventricular Function by Speckle Tracking Echocardiography in Patient Hospitalised in Intensive Care Unit for Vaso-occlusive Crisis

Bicetre Hospital

Status: Unknown

Conditions: Sickle Cell Disease

Treatments: Other: Evaluation of global longitudinal strain using routinely recorded echocardiography images

Study type: Observational

Funder types: Other

Identifiers

NCT04864041

2021-A00623-38

Details and patient eligibility

About

Vaso-occlusive crisis in Sickle cell disease might alter myocardial function through micro vascular obstruction. Evaluation of strain alteration using speckle tracking echocardiography is a non invasive technique that may allow us to observe such myocardial dysfunction. No such study has yet been conducted in patient hospitalised in intensive care unit. Our hypothesis is that strain alteration during vaso-occlusive crisis, if they do exist, can be correlated with other markers of myocardial injury such as troponin level or thoracic pain.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hospitalisation in an intensive care unit for vaso-occlusive crisis

Exclusion criteria

• Pregnancy
• Individuals under guardianship
• Unsufficient echogenicity
• Thoracic pain prohibiting echocardiography assessment

Trial design

30 participants in 1 patient group

Patients hospitalised in ICU for vaso-occlusive crisis

Treatment:

Other: Evaluation of global longitudinal strain using routinely recorded echocardiography images