Evaluation of Lipid Emulsion on GCX in Critically Ill Patients

University Hospital Hradec Kralove

Status: Completed

Conditions: Endothelial Dysfunction

Treatments: Device: Sublingual microcirculation assessment

Study type: Observational

Funder types: Other

Identifiers

NCT03216850

AZVCR 9307_5/a

Details and patient eligibility

About

Characterisation of the lipidome and parenteral nutrition modulate the endothelial glycocalyx.

The aim of the study A is to detect any influence of the lipid emulsion on the endothelial glycocalyx in patients in critical care. The targeted cohort is patients on ICU with an indication for parenteral nutrition including lipid emulsion. 15 patients are planned to be enrolled.

Monitored variables: demographic data, type of the population, type of the lipid emulsion, selected variables of the lipid metabolism, sublingual microcirculation (SDF imaging),

Enrollment: 15 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients in ICU
• indication for lipid administration as a part of TPN

Exclusion criteria

• shock or clinical/laboratory signs of tissue hypoperfusion
• previous lipid infusions (within 3 months before entering study)
• hyperlipidaemia
• hyperglycaemia (over 10 mmol/l)
• current or previous (within 72 hours before entering the study) use of propofol
• pancreatitis
• severe liver failure
• current use of statins

Trial design

15 participants in 1 patient group

Patients in ICU requiring parenteral nutrition

Treatment:

Device: Sublingual microcirculation assessment