Evaluation of Lung Atelectasis During Apneic Oxygenation Using THRIVE in Adults During Laryngeal Surgery. (A-THRIVE)

Karolinska University Hospital

Status: Completed

Conditions: Anesthesia

Treatments: Device: THRIVE; Device: Endotracheal intubation

Study type: Interventional

Funder types: Other

Identifiers

NCT03458091

A-THRIVE

Details and patient eligibility

About

Oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing. The THRIVE technique is able to oxygenate patients safely and vital parameters has been shown to be stable. But it is of great importance to evaluate this new concept regarding other potential negative physiological aspects such as lung atelectasis and inflammatory stress response before implementing it into clinical practice.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Adults, >18 years old.
2. ENT-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery).
3. Capable of understanding the study information and sign the written consent.

Exclusion criteria

1. ASA>2
2. NYHA >2
3. Pacemaker or ICD.
4. BMI >35
5. Pregnancy
6. Manifest cardiac failure or coronary disease
7. Severe gastrointestinal reflux.
8. Neuromuscular disorder

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Intubation

Active Comparator group

Description:

The patients will be intubated and ventilated

Treatment:

Device: Endotracheal intubation

THRIVE

Experimental group

Description:

The patients will be oxygenated during apnea using THRIVE

Treatment:

Device: THRIVE