Evaluation of Lung Deposition of Aerosol Via HFNC in Healthy Adults

Universidade Federal de Pernambuco

Status: Unknown

Conditions: Healthy

Treatments: Other: 50l/min; Other: 10l/min; Other: 30l/min

Study type: Interventional

Funder types: Other

Identifiers

NCT02519465

Luciana doutorado 02

Details and patient eligibility

About

The aerosol associated with noninvasive ventilation (NIV) and high flow therapy with nasal interface have been employed in an attempt to relieve respiratory distress and optimize the deposition of drugs by inhalation.

Some studies report the effects of NIV association with fogging in healthy subjects, asthmatics and COPD 7.8, but studies evaluating the association between high flow nasal mist interface and therapy are scarce and most are found in vitro and animal models. The objective of this study is to evaluate the deposition of the aerosol scintigraphy using the high flow nasal interface system with vibrating mesh nebulizers using in healthy adults.

Enrollment: 25 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The study included healthy individuals of both sexes,
• between 18 to 65 years,
• without history of lung disease and forced vital capacity (FVC) or forced expiratory volume in the first second (FEV1) higher or equal to 80% from predicted values,
• ability to verbal commands understand and
• willing to provide signed consent to participate in this study.

Exclusion criteria

• Participants were excluded if there unable to understand and follow the procedures and were pregnant and unable to tolerate nebulization.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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25 participants in 2 patient groups

HEATED FLOW

Active Comparator group

Description:

The volunteers were randomly allocated into three groups - group 1 - 10l/min cold or heated, group 2 - 30l/min cold or heated, group 3 - 50 l /min - cold or heatedPhase 1 - 10l/min or 30l/min or 50l/min of the oxygen heated .

Treatment:

Other: 50l/min

Other: 30l/min

Other: 10l/min

COLD FLOW

Active Comparator group

Description:

The volunteers were randomly allocated into three groups - group 1 - 10l/min cold or heated, group 2 - 30l/min cold or heated, group 3 - 50 l /min - cold or heatedPhase 1 - 10l/min or 30l/min or 50l/min of the oxygen cold

Treatment:

Other: 50l/min

Other: 30l/min

Other: 10l/min