Evaluation of Lycopene in the Treatment of Erosive Oral Lichen Planus

Nourhan M.Aly

Status and phase: Completed; Phase 3; Phase 2

Conditions: Erosive Lichen Planus

Treatments: Drug: Lycopene Softgel, 10 Mg; Drug: Prednisolone

Study type: Interventional

Funder types: Other

Identifiers

NCT04652739

Lycopene and lichen planus

Details and patient eligibility

About

The aim of this study was to evaluate the effect of oral lycopene and systemic steroids in the treatment of erosive oral lichen planus and compare between the two therapeutic modalities.

Full description

Twenty erosive lichen planus patients were recruited and randomly assigned in one of two groups, the test (lycopene) and control (corticosteroids) group.

Enrollment: 20 patients

Sex: All

Ages: 30 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Erosive oral lichen planus patients with severe and extensive painful erythematous, erosive and/ or ulcerative lesions who are in need for systemic corticosteroid therapy

Exclusion criteria

• Pregnant females and smokers.
• Patients suggestive of having lichenoid contact/drug reactions.
• Patients suffering from any systemic disease as diabetes, liver disease, renal disease, any other autoimmune or collagen disease.
• Lesions showing histological features of dysplasia.
• Patients with skin lichen planus lesions.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Lycopene

Experimental group

Treatment:

Drug: Lycopene Softgel, 10 Mg

Corticosteroids

Active Comparator group

Treatment:

Drug: Prednisolone