Evaluation of Metabolomic Analysis in Early Diagnosis of ALS (METABALS)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: ALS

Treatments: Procedure: lumbar puncture

Study type: Interventional

Funder types: Other

Identifiers

NCT01962311

2012-A00145-38 (Other Identifier)

PHRN11-CA-METABALS

Details and patient eligibility

About

This project is expected to answer the question of interest assays of metabolites in the CSF as a tool for early diagnosis and should show whether it is possible or not to use such markers in the blood or urine. These studies should also help shed light on the pathophysiological original early clinical disease. While ALS appears to be more a clinical syndrome that pathophysiological entity unique metabolic abnormalities identified could help identify mechanisms disrupted in which therapeutic interventions will be possible.

Full description

A blood test that would allow the diagnosis

1. to reduce the time between the first signs and diagnosis in ALS patients for therapeutic treatment earlier and
2. to exclude rapidly non ALS in their avoiding unnecessary investigations and anxiety of being infected with a terrible prognosis disease. It is currently accepted that neurodegenerative diseases such as ALS begin before the first clinical signs and the patient could benefit from a more efficient care if it was early.

Conduct a prospective study with 400 patients.

The secondary objectives are:

1. attempt to improve the predictive power of markers assays by adding new parameters
2. to check whether the assayed molecules in other environments more accessible (blood, urine) would provide equivalent diagnostic power of those assayed in the CSF
3. identify metabolic pathways disrupted early that could be related to the pathogenesis of neurodegeneration.

Enrollment: 82 patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 30-80
• Consent signed
• affiliation to a social security organism

Exclusion criteria

• Patients treated with RILUZOLE
• Enrollment in an other study

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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82 participants in 1 patient group

All patients

Experimental group

Description:

lumbar puncture

Treatment:

Procedure: lumbar puncture