Evaluation of Microcirculation With Photoplethysmography (Pulse Oximetry) in Healthy Volunteers and Ventilated Patients

Hospital Privado de Comunidad de Mar del Plata

Status: Enrolling

Conditions: Photoplethysmography; Microcirculation

Treatments: Other: photoplethysmography

Study type: Observational

Funder types: Other

Identifiers

NCT06141681

UCI-000004

Details and patient eligibility

About

The objective of this observational study is to explore microcirculation in healthy volunteers and in ventilated patients in the operating room and in critical care.

The general objective of this study is to evaluate microcirculation with photoplethysmography (PPG) in different pathophysiological situations and to compare PPG with available standard methods. Specifically, evaluate the correlation between the determinations of AC-DC waves obtained by Photoplethysmography (PPG) and those obtained in different dynamic tests in healthy volunteers.

To compare microcirculation assessments [capillary refill time (CRT), perfusion index (PI), perfusion index variability (PIV)] with measurements obtained by PPG in the context of critically ill patients.

To compare microcirculation assessments (CRT, PI PVI) with measurements obtained by PPG in the context of patients on invasive mechanical ventilation (IMV) in the operating room and in critical care.

Full description

An attempt is made to explore different physiological aspects that affect microcirculation such as vascular tone and blood volume.

Photoplethysmography usually examines the AC wave equivalent to the pulsatile wave, however the DC component has been less explored and can account for the microcirculation and volemia status of the subjects.

Since there is no gold standard, it will be compared against different validated methods.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Healthy Volunteers:

Inclusion Criteria:

• Written informed consent.
• Age > 18 years.

Exclusion Criteria:

• Pregnancy.
• Smokers.
• Respiratory and/or cardiovascular pathologies.
• Peripheral vascular disease.

Operation room or Critical care Unit patients

Inclusion criteria:

• Written informed consent.
• Age > 18 years.
• Critical patients ventilated in the ICU of any origin.

Exclusion criteria:

• Known peripheral vascular disease.
• Burns on both upper limbs.
• Trauma to both upper limbs.

Trial design

20 participants in 3 patient groups

Healthy volunteers

Description:

\>18 years old healthy

Treatment:

Other: photoplethysmography

Patients in critical care unit

Description:

patient in ICU with requirement for hemodynamic monitoring

Treatment:

Other: photoplethysmography

Patients with ventilatory support in the operating room or critical care unit

Description:

patient in the ICU or operating room with a requirement for hemodynamic monitoring and ventilatory support

Treatment:

Other: photoplethysmography