Evaluation of Myocardial Perfusion Reserve (EVARESERVE)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Device: CZT SPECT camera

Study type: Interventional

Funder types: Other

Identifiers

NCT02773043

38RC14.214

Details and patient eligibility

About

The proposed study is to validate a non-invasive imaging technique to evaluate the myocardial perfusion reserve in comparison with a validated invasive technique, the measure of coronary flow reserve (CRF) with thermodilution.

Full description

Coronary artery disease is a public health problem. The measurement of myocardial perfusion reserve is a prognostic factor supplemental.

Its measure should influence the treatment and the follow up of the patients. The measurement of CRF by by one pressure-temperature sensor-tipped guide wire is a validated technique to evaluate the myocardial perfusion reserve but it is an invasive technique.

In this study, the investigators will compare this method with a non-invasive method: completely automated analysis and quantification of myocardial blood flow from DICOM files corresponding to stress and rest images was developed with a new camera CZT SPECT.

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Myocardial scintigraphy with pharmacologic stress and abnormal results
• Coronarography indicated
• Informed consent

Exclusion criteria

• Pregnant woman
• Patient with terminal illness
• Terminal renal failure
• Allergy to iodine
• Informed consent impossible
• Patient under legal protection
• History of coronary artery bypass surgery
• Contraindications for adenosine: asthmatic patients, second or third-degree AV block without pacemaker or sick sinus syndrome. Systolic blood pressure less than 90 mmHg. Recent use of dipyramidole or dipyramidole-containing medications. Methyl xanthenes such as aminophylline caffeine or theobromine block the effect of adenosine and should be held for at least 12 hours prior to the test. Known hypersensitivity to adenosine. Unstable acute myocardial infarction or acute coronary syndrome.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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36 participants in 1 patient group

non invasive imaging technique

Other group

Treatment:

Device: CZT SPECT camera