Evaluation of Negative Symptoms and Cognitive Function After Administration of Antipsychotics in Healthy Volunteer

Chonbuk National University

Status: Completed

Conditions: Normal Volunteers

Treatments: Drug: aripiprazole; Drug: haloperidol; Drug: amisulpride; Drug: risperidone; Drug: lactose

Study type: Observational

Funder types: Other

Identifiers

NCT01185418

CBIRB0226-22

Details and patient eligibility

About

The aim of the study is to investigate the negative symptoms and cognitive function after administration of antipsychotics in healthy volunteer.

Enrollment: 80 patients

Sex: All

Ages: 18 to 38 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 18-38 years and meet no DSM-IV diagnostic criteria as assessed by using the Structured Clinical Interview for DSM-IV, research version.

Exclusion criteria

• 1. anyone who participated in other clinical trials within 30 days from the start of this clinical trial or is currently participating in one,
• 2. anyone who has progressive disease or in unstable medical condition unfit for the trial,
• 3. anyone who has been diagnosed in psychiatric terms in the past, depends on psychotropic substance, or has overdosed or depended on the substance or alcohol (except for coffee or tobacco) within 1 month from the trial start,
• 4. anyone who is suicidal or highly probable of suicides, or
• 5. anyone who has test results considered clinically meaningful

Trial design

80 participants in 5 patient groups

risperidone

Treatment:

Drug: risperidone

aripiprazole

Treatment:

Drug: aripiprazole

haloperidol

Treatment:

Drug: haloperidol

amisulpride

Treatment:

Drug: amisulpride

lactose

Treatment:

Drug: lactose