Evaluation of Neoadjuvant Therapy Efficacy and Postoperative Pathological Indicators in Esophageal Cancer Using CT and Multimodal MRI

Henan Cancer Hospital

Status: Not yet enrolling

Conditions: Esophageal Cancer; Neoadjuvant Therapy

Study type: Observational

Funder types: Other

Identifiers

NCT06833775

2024-621

Details and patient eligibility

About

This study aims to predict the efficacy of different types of neoadjuvant therapy and related postoperative pathological indicators in patients with esophageal cancer based on imaging parameters from CT and multimodal MRI, as well as clinical indicators collected before and after neoadjuvant treatment.

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Consecutive patients with histopathological diagnosis of esophageal cancer.
2. Patients underwent neoadjuvant therapy before radical surgery for esophageal cancer: neoadjuvant chemotherapy, neoadjuvant chemoradiotherapy, neoadjuvant chemotherapy plus immunotherapy, neoadjuvant chemoradiotherapy plus immunotherapy.
3. All patients underwent CT and multimodal MRI examinations before and after neoadjuvant therapy.
4. The preoperative clinical data and postoperative pathological data are complete.

Exclusion criteria

1. Patients with other primary malignant tumors or previous anti-tumor treatment.
2. CT and MRI images with poor quality.

Trial design

400 participants in 2 patient groups

the group of patients who achieved pathological complete response (pCR) following neoadjuvant

the group of patients who did not achieve pCR following neoadjuvant therapy and surgery for esophage