Evaluation of Neopterin Levels in Pre and Post-menopausal Women With Periodontitis Following Non Surgical Therapy (ENLPPMNS)

Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre

Status: Unknown

Conditions: Periodontitis

Treatments: Procedure: Non surgical periodontal therapy

Study type: Observational

Funder types: Other

Identifiers

NCT02357745

suma thesis

Details and patient eligibility

About

Neopterin has been identified as a marker of cellular immune system activation. It is synthesized by macrophages upon stimulation with the cytokine interferon-gamma and is indicative of a pro-inflammatory immune status. Neopterin concentration increases with increasing severity of periodontal disease in diverse body fluids like Urine, Saliva and Plasma. Hence Neopterin can be considered as an important inflammatory marker in periodontal disease as well as other systemic diseases.

Full description

At baseline - plasma, urine and saliva samples were collected and analysed for neopterin levels from the pre and post-menopausal women with periodontitis . Followed by scaling and root planing done in both the groups. After 3 months again these 3 samples were collected and analysed for post treatment neopterin levels

Enrollment: 30 estimated patients

Sex: Female

Ages: 40 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• moderate to chronic periodontitis
• non-smokers
• minimum 15 natural teeth present

Exclusion criteria

• patients on long term steroid medication
• with gross oral pathology or tumors
• undergoing hormone replacement therapy
• not undergone periodontal therapy in past 6 months
• under medication in past 6 months
• systemic disorders and drugs which influence the periodontium

Trial design

30 participants in 2 patient groups

Pre-menopausal with periodontitis

Description:

non surgical periodontal therapy ( scaling and root planing)

Treatment:

Procedure: Non surgical periodontal therapy

Post-menopausal with periodontitis

Description:

non surgical periodontal therapy ( scaling and root planing)

Treatment:

Procedure: Non surgical periodontal therapy