Evaluation of Neuroinflammation in Children With Infantile Spasms

Wayne State University

Status and phase: Completed; Phase 4

Conditions: Infantile Spasms

Treatments: Drug: ACTH

Study type: Interventional

Funder types: Other

Identifiers

NCT02092883

25QNC

Details and patient eligibility

About

The purpose of this study was to investigate the presence of neuroinflammation in children with infantile spasms using 11C-PK11195 positron emission tomography (PK PET) scan, and its response to ACTH treatment by repeating the PK PET scan after treatment.

Enrollment: 8 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• A clinical diagnosis of 'cryptogenic IS'
• Normal MRI
• No other neurological disorder

Exclusion criteria

• Abnormal MRI
• No anti-inflammatory medication 48 hrs prior to PK PET scans
• Parent/guardian unable to give written consent

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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8 participants in 1 patient group

Infantile Spasms

Experimental group

Treatment:

Drug: ACTH