Evaluation of Neuroprotective Effect of Minocycline (minocyclin &RD)

Shahid Beheshti University of Medical Sciences

Status and phase: Unknown; Phase 2

Conditions: Retinal Detachment

Treatments: Drug: Minocycline; Drug: placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01297816

89122

Details and patient eligibility

About

This process appears as a incredible and progressive event that will not stop till reattachment of RPE and neurosensory retina happened .

Process of degeneration begins from first hours of RD (Retinal Detachment) establishment Neuroprotection of photoreceptor following RD is a novel and debatable discussion encountered in recent years .

How to stop this phenomena and neuroprotective agent role in this issue are a new interest of researcher.

In the study the investigators are planning to perform a clinical trial to demonstrate the minocycline neuroprotective effect in a double blind design as this impact has been implicated previously in a animal study

Sex: All

Ages: 8+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age over 8 years old
• gender of both sex
• normal liver and renal function
• informed consent received from all patients
• no pregnancy and no lactation
• minimal sun exposure

Exclusion criteria

• old RD
• diabetic retina
• previous retinal surgery CRF& liver disfunction RD + PVR > B Hyper sensitivity to tetracycline History previous MPC or PRP Patients unsuccessful SB (retina is off )

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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0 participants in 2 patient groups, including a placebo group

placebo

Placebo Comparator group

Description:

100mg-

Treatment:

Drug: placebo

minocyclin

Placebo Comparator group

Treatment:

Drug: Minocycline