EVALUATION OF NEUTROPHIL FLUORESCENCE IN PATIENTS WITH DISSEMINATED INTRAVASCULAR COAGULATION ASSOCIATED WITH SEPTIC SHOCK (HEMATOCLOT)

University Hospital, Strasbourg, France

Status: Not yet enrolling

Conditions: DISSEMINATED INTRAVASCULAR COAGULATION ASSOCIATED WITH SEPTIC SHOCK

Treatments: Other: Blood sampling collection

Study type: Observational

Funder types: Other

Identifiers

NCT07039487

9556

2024-A02853-44 (Other Identifier)

Details and patient eligibility

About

Neutrophil fluorescence could be a reliable and early diagnostic marker of disseminated intravascular coagulation septic DIC, which can be used routinely. The objective of the investigators is to define the optimal threshold of neutrophil fluorescence associated with a sensitivity of at least 90% for the diagnosis of DIC.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or female ≥ 18 years of age
• Patient admitted to intensive care for septic shock
• Patient affiliated to a social security scheme or entitled to it
• Non-opposition by the patient or a relative in the event that the patient is not in a state to express his or her consent or inclusion in an emergency procedure in the event that the patient is not in a state to express his or her opinion and no relative of the patient can be reached.

Exclusion criteria

• Dying patient on the day of inclusion
• Cirrhosis Child Pugh C
• Neutropenia (<500 mm3)
• Patient under judicial protection
• Patient under guardianship or curatorship
• Pregnancy
• Breastfeeding