Evaluation of Non Specific Symptoms and Quality of Life Before and After Surgery for Mild Primary Hyperparathyroidism

Nantes University Hospital (NUH)

Status: Completed

Conditions: Primary Hyperparathyroidism

Study type: Observational

Funder types: Other

Identifiers

NCT01776502

RC12_0255

Details and patient eligibility

About

The purpose of this study is to evaluate the evolution of the non specific symptoms for 116 patients with mild primary hyperparathyroidism before and 3, 6 and 12 months after surgery. A clinical score predicting clinical improvement at one year will be created.

Enrollment: 116 patients

Sex: All

Ages: Under 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects with known moderate HPTI will be considered for participation.

Patients with sporadic mild HPTI defined by:

• calcemia > 2.6 mmol/L , PTH > 25 ng/L and creatininemia < 160µmol/L OR
• calcemia between 2.5 and 2.6 mmol/L and PTH > 35 ng/L
• calcemia ≤2.85 mmol/L
• urine calcium level / 24 hours < 10 mmol (400 mg),
• decrease of the creatinin's clearance : 30% lower than normal population with the same age
• patients younger than 50
• patients who can't be followed

Exclusion criteria

• familial hypercalcemia
• multiple endocrinal neoplasia
• treatment with lithium or thiazides
• impossibility for the patient to complete the forms
• impossibility to follow the patient
• patient with serious disease which impact the quality of life

Trial design

116 participants in 1 patient group

Patients with Hyperparathyroidism

Description:

The cohort of patients is made of patients with primary mild hyperparathyroidism and who have received a surgery at Nantes, Angers, Limoges or Marseille University Hospitals