Evaluation of Novel Lung Function Parameters in Patients With Pulmonary Hypertension (PH)

Universitätsmedizin Mannheim

Status: Completed

Conditions: Pulmonary Hypertension

Treatments: Diagnostic Test: impulse oscillometry; Diagnostic Test: multiple breath washout; Diagnostic Test: body plethysmography

Study type: Observational

Funder types: Other

Identifiers

NCT03667794

MBW-PH

Details and patient eligibility

About

Little is known about affection of small airways in patients with pulmonary hypertension as well as the ideal diagnostic approach. The investigators therefore aimed to evaluate novel or not widely used lung function tests for the evaluation of airway function in patients with PH.

Enrollment: 75 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• known or first diagnosis of PH

Exclusion criteria

• inability to perform lung function testing
• unable or unwilling to participate

Trial design

75 participants in 3 patient groups

PH patients

Description:

Patients with known or first diagnosis of PH

Treatment:

Diagnostic Test: body plethysmography

Diagnostic Test: multiple breath washout

Diagnostic Test: impulse oscillometry

healthy controls

Description:

Healthy controls had normal lung function testing including whole-body plethysmography and transfer factor, no previously diagnosed pulmonary disease as well as no respiratory symptoms.

Treatment:

Diagnostic Test: body plethysmography

Diagnostic Test: multiple breath washout

Diagnostic Test: impulse oscillometry

non-healthy controls

Description:

Non-healthy controls were allowed to have stable pulmonary comorbidities including chronic obstructive pulmonary disease (COPD), sarcoidosis, asthma, or fibrosis as well as non-pulmonary comorbidities.

Treatment:

Diagnostic Test: body plethysmography

Diagnostic Test: multiple breath washout

Diagnostic Test: impulse oscillometry