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Evaluation of Ocular Lens Proteins in Cataract From Individuals With Down Syndrome

University of Colorado Denver (CU Denver) logo

University of Colorado Denver (CU Denver)

Status

Terminated

Conditions

Cataract
Down Syndrome

Treatments

Procedure: cataract surgery

Study type

Observational

Funder types

Other

Identifiers

NCT03778528
17-0372

Details and patient eligibility

About

This study involves the collection ocular lens tissue from individuals with Down syndrome and age-matched controls at the time of cataract surgery.

Full description

Individuals with Down syndrome have an increased rate of cataract. The reason for this increase is unclear. Normally, once cataracts become a significant impairment, an ophthalmologist will determine when cataract surgery should be performed. When this surgery is performed, cataractous tissues are cut out and discarded with medical waste. In this study, these tissue will be collected and protein analysis performed to determine what changes in different proteins are found in Down syndrome lenses as compared to normal cataractous lenses.

Enrollment

1 patient

Sex

All

Ages

1 month to 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Undergoing cataract surgery for lens extraction.

Exclusion criteria

  • Known genetic cause other than Down syndrome causing cataract.

Trial design

1 participants in 2 patient groups

Down syndrome
Description:
Individuals with Down syndrome undergoing cataract surgery.
Treatment:
Procedure: cataract surgery
Control
Description:
Age-matched controls undergoing cataract surgery.
Treatment:
Procedure: cataract surgery

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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